We Provide In-Depth Single-Molecule Proteomics Analysis
Nanopore sensors have single-molecule sensitivity which is about 1 million times better than the current gold standard mass spectrometry (MS). Statistical analysis over time (which is accellerated by nanopore multiplexing) allows for absolute and relative quantification of low abundant proteins which is achieved with chemically functionalized serial nanopores.
90% of FDA approved drugs target a protein but understanding drugs-protein interactions is time consuming, expensive, and often inconclusive. The reason is often too little knowledge about site-specific post-translational modifications. We can measure site-specific glycosylation or phosphorylation and help to draw conclusions from drug-protein interactions.
We are currently improving our sensor to site-specifically detect all amino acids in the backbone of proteins and therefore be the first technology allowing for whole protein sequencing.